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Cutaneous bronchogenic cyst in the left scapular region 
 
Cutaneous bronchogenic cyst in the left scapular region
  Jian Sun, Ting Yuan, Huan Deng
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Cutaneous bronchogenic cyst in the left scapular region of a boy
 
Jian Sun, Ting Yuan, Huan Deng
Nanchang, China
 
Author Affiliations: Department of Pathology, Fourth Affiliated Hospital, Nanchang University, Nanchang, China (Sun J, Yuan T, Deng H); Renmin Institute of Forensic Medicine, Nanchang, China (Deng H)
 
Corresponding Author: Huan Deng, MD, PhD, Department of Pathology, Fourth Affiliated Hospital, Nanchang University, 133 South Guangchang Road, Nanchang, Nanchang 330003, China (Tel: +86 791 87022537; Email: beandeng@hotmail.com)
 
doi: 10.1007/s12519-014-0514-9
 
 
Background: Scapular bronchogenic cyst (SBC) is rare.
 
Methods: A sinus on a boy's left scapula was excised.
 
Results: Histopathological analysis showed the epithelium with scattered PAS-positive goblet cells was positive for CEA and CK7.
 
Conclusion: SBC should be suspected of a superficial scapular skin lesion in children.
 
World J Pediatr 2014;10(4):365-367
 
Key words: bronchogenic cyst;
           immunohistochemistry;
           scapula
 
 
Introduction
Cutaneous bronchogenic cyst (CBC) is uncommon, and its scapular location indicates an infrequent form of this condition. The cystic lesions are characteristically lined with ciliated pseudostratified columnar epithelium (CPCE) interspersed with goblet cells and are surrounded by smooth cell bundles, seromucous glands and mature cartilage, all of which can be found in the respiratory system. Although it has been extensively accepted that the cysts derive from abnormal tracheobronchial buds, the mechanism for the pathogenesis is unclear.
In this report, we described a case of a boy with CBC in his left scapular region and studied the gross, histologic and immunohistochemical features of the cyst.
 
 
Case report
An 18-month-old boy presented with a 1 cm diameter draining sinus in his left scapula area. A painless skincolored mass was noted shortly after his birth, and it was incised and drained when he was 12-month-old, causing repeated infection. Physical examination revealed a cavity measuring 20¡Á15 mm2 in size. No abnormalities were found by laboratory examination. After the resection of the lesion under local anesthesia, the cavity was found to be filled with purulent secretion and mucoid fluid.
Histologically, the inner surface of the sinus was lined with ciliated pseudostratified columnar epithelium and partially with squamous epithelium (Fig. A). Scattered goblet cells among respiratory-type epithelium were positive for periodic acid-schiff staining (PAS) (Fig. B). The following findings were also observed: seromucous glands deep in the cavity wall (Fig. C&D), smooth muscle bundles, sweat glands stretching from the connective tissue to the surface of the cavity (Fig. E), granulation tissue and several lymphoid follicles (Fig. F).
Ciliated pseudostratified columnar epithelium displayed immunoreactivity for CK7 but was negative for CK20 (Fig. G). The respiratory-type epithelium was positive for carcinoembryonic antigen (CEA) (Fig. H) but not for thyroid transcription factor 1 (TTF-1) (Fig. I), which is expressed in the normal pulmonary airways. CDX-2 was negative in all elements of the cyst, and less than 5% of the cyst was Ki-67 labeled. These histological and immunohistochemical findings were consistent with a diagnosis of scapular bronchogenic cyst (SBC).
 
 
Discussion
Bronchogenic cyst (BC) in the scapular area is extremely rare, and only 16 cases have been reported in the literature (Table). Because of its congenital origin and superficial location, the cyst is mostly observed in children, particularly in boys (a boy/girl ratio of 4:1).[1]
Bronchogenic cyst is usually found in the chest cavity or mediastinum.[3] Two hypotheses regarding its pathogenesis have been reported. One is that ciliated pseudostratified columnar epithelium (CPCE) of the cyst may be derived from mature pre-existing cutaneous tissue by metaplasia. Several studies[2,5,7,9,11,12] including the present one observed the transition from CPCE to squamous epithelium, sebaceous glands and sweat glands in the cystic wall. However, CPCE is often associated with respiratory mesenchymal components such as smooth muscle bundles, seromucous glands and cartilage;[1,3-7] this fact may support that the misplaced epithelium made alterations to the surrounding environment and further induced the formation of tracheal-bronchial wall elements.[8,10]
Another hypothesis emphasizes an important role of abnormal tracheal buds in the occurrence of BC. These tracheal buds are pinched off and leave respiratory tissue before or after the fusion of the mesenchymal bars at about the ninth week. Therefore, these cysts may be located between the trachea and esophagus, namely in the suprasternal notch, presternal area and thoracic cavity.[2,3,9] A minority of BCs expressing TTF-1 suggests that the eventual immunostaining pattern depends on the stage of development in which the errors occur. However, significant challenge still exists before this prevalent theory can be widely accepted. That is, the complicated route of migration and the unbalanced male-to-female ratio.
Definitive diagnosis mainly depends on histologic evaluation, i.e., respiratory-type epithelium with PAS-positive goblet cells lining the cyst walls beneath with abundant lymphoid tissue, often with germinal centers, circumferential smooth muscle bundles, seromucous glands, and cartilage.[5] Secondary infection can induce granulation tissue formation. Differential diagnosis includes cystic mature teratoma, ectopic salivary tissue, thyroglossal duct cyst, branchial cleft cyst, epidermoid cyst and other skin adnexal cysts. Teratoma can be diagnosed only when tridermic lineage is present. Branchial cleft cysts share many histologic features with BCs, including respiratory epithelium, squamous epithelium, lymphoid tissue, smooth muscle and seromucous glands. Despite possible histological overlap, the location in the anterolateral region of the neck favors the diagnosis of branchial cleft cyst. Keratinizing squamous epithelium and the absence of seromucous glands are useful for distinguishing epidermoid cysts from BCs. Immunohistochemistry and PAS staining are useful but not necessary for the differential diagnosis.
Although BCs are benign lesions, complete surgical excision is advised due to the risk of repeat infection and malignant transformation, such as adenocarcinoma, malignant melanoma and malignant pleural mesothelioma.[12]
 
 
Funding: This study was supported by grants from National Natural Science Foundation of China (No. 81300347) and Natural Science Foundation of Jiangxi Province of China (No. 20132BAB205037).
Ethical approval: Not needed.
Competing interest: None.
Contributors: Deng H wrote the first draft of this paper. Deng H and Sun J analyzed the pathological and immunohistochemical data. All the authors contributed to the intellectual content and approved the final version.
 
 
References
1   Pul N, Pul M. Bronchogenic cyst of the scapular area in an infant: case report and review of the literature. J Am Acad Dermatol 1994;31:120-122.
2   Miller OF 3rd, Tyler W. Cutaneous bronchogenic cyst with papilloma and sinus presentation. J Am Acad Dermatol 1984;11:367-371.
3   Fraga S, Helwig EB, Rosen SH. Bronchogenic cysts in the skin and subcutaneous tissue. Am J Clin Pathol 1971;56:230-238.
4   Yu HJ, Kwon HM, Park JW, Hwang DK, Ahn DK, Park YW. A case of cutaneous bronchogenic cyst over the left scapula. J Dermatol 2001;28:572-575.
5   Tresser NJ, Dahms B, Berner JJ. Cutaneous bronchogenic cyst of the back: a case report and review of the literature. Pediatr Pathol 1994;14:207-212.
6   Jona JZ. Extramediastinal bronchogenic cysts in children. Pediatr Dermatol 1995;12:304-306.
7   van der Putte SC, Toonstra J. Cutaneous 'bronchogenic' cyst. J Cutan Pathol 1985;12:404-409.
8   Manconi R, Bolla G, Pavon I. Congenital bronchogenic subcutaneous cyst of the back. A case report and review of the literature. Pediatr Med Chir 2003;25:364-366. [in Italian]
9   Ozel SK, Kazez A, Koseogullari AA, Akpolat N. Scapular bronchogenic cysts in children: case report and review of the literature. Pediatr Surg Int 2005;21:843-845.
10 Kundal AK, Zargar NU, Krishna A. Scapular bronchogenic cyst. J Indian Assoc Pediatr Surg 2008;13:147-148.
11 Al-Balushi Z, Ehsan MT, Al Sajee D, Al Riyami M. Scapular bronchogenic cyst: a case report and literature review. Oman Med J 2012;27:161-163.
12 Nakamura Y, Fujishima F, Ito S, Ishida K, Sato S, Watanabe M, et al. A case of cutaneous bronchogenic cyst in the scapular area. Pol J Pathol 2011;62:120-121.
                                             
                                                                                           Received August 27, 2013
                                                                           Accepted after revision February 6, 2014
 
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