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Author Affiliations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA (Leibowitz KL, Stallings VA, Berkowitz RI, Faith MS, Stettler N); UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA (Leibowitz KL); University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA (Moore RH, Ahima RS, Stunkard AJ, Stallings VA, Berkowitz RI, Chittams JL, Faith MS, Stettler N)
Corresponding Author: Karen L. Leibowitz, MD, Department of Pediatrics, Division of Gastroenterology and Nutrition, UMDNJ-RWJMS, 89 French Street, 2nd Floor, New Brunswick, NJ 08901, USA (Tel: 732-235-6109; Fax: 732-235-6381; Email: leibowka@umdnj.edu)
doi: 10.1007/s12519-011-0292-6
Background: This study explored the association between maternal obesity during pregnancy and the inflammatory markers, tumor necrosis factor-¦Á, interleukin-6 and high sensitivity C-reactive protein (hs-CRP), and the cytokine, adiponectin, in the offspring.
Methods: Weight, height, Tanner stage and biomarkers were measured in thirty-four 12-year-old children, from the Infant Growth Study, who were divided into high risk (HR) and low risk (LR) groups based on maternal pre-pregnancy body mass index (BMI).
Results: The two groups differed markedly in their hs-CRP levels, but no group difference was found for the other three biomarkers. The odds ratio (OR) of HR children having detectable hs-CRP levels was 16 times greater than that of LR children after adjusting for confounding variables, including BMI z-score, Tanner stages and gender (OR: 16; 95% CI: 2-123).
Conclusions: These results suggest that maternal obesity during pregnancy is associated with later development of elevated hs-CRP in the offspring, even after controlling for weight.
Key words: children; hs-C-reactive protein; inflammation; maternal obesity
World J Pediatr 2012;8(1):76-79
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